The diet consists of food groups that contain macro and micronutrient components that provide the vital needs of our body. There are also bioactive components that play a role in human metabolism in the contents of foods. In addition to the individual effects of nutritional components, the level of interaction between nutrients, that is, the quality of the diet, is also effective on our health. In addition to changing living conditions and dietary habits, the increase in diseases today reveals the importance of preventive medicine protocols. Experimental and clinical studies showing that diseases can be prevented with correct nutritional approaches and living habits are increasing day by day. Data obtained from numerous scientific studies conducted among populations reveal that nutrition also plays an important role, as well as genetic composition, which is the most determining factor in the initial emergence of diseases. The basis of human nutrition is the energy needs that change according to the growth and development stages and the macro and micro nutrients that will allow the necessary biological functions to be realized. While normal biological functions are fulfilled with a balanced nutrition approach, these nutrients are also used in the synthesis of new nutrients. When you compare yourself to a friend or family member, “She eats many times more than me, but I gain weight. You may have said that if I drink water, it works. It is very normal for us to think that if we are genetically different from each other, we can respond differently to the same lifestyle and diet. The daily fat consumption rate and special cooking techniques of an individual with a high fat intolerance must be an extremely important dietary recommendation. Careful implementation of the recommendations of the individual's cuisine and lifestyle changes in order to reorganize the diet and limit the consumption of packaged food in order to ensure the iodine balance of a patient with high salt sensitivity does not change the genetic structure of the individual, but it is important in the protection of health as an epigenetic change affecting the expression of genes. Evaluating the genetic structure of an individual in terms of all sensitivities and considering the current health status will bring a holistic life transformation supported by epigenetic nutrition.